1-[3-(2,3-Dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine → 1-(3-Indol-1-yl-propyl)-1H-pyrazol-4-ylamine

HRID 624024Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 624024
[N:1]1([CH2:10][CH2:11][CH2:12][N:13]2[CH:17]=[C:16]([NH2:18])[CH:15]=[N:14]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1>CC(C)=O.O=[Mn]=O>[N:1]1([CH2:10][CH2:11][CH2:12][N:13]2[CH:17]=[C:16]([NH2:18])[CH:15]=[N:14]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Komponenten

4

Edukt 1

HCID 682827791-[3-(2,3-Dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine

Produkt 1

HCID 682831811-(3-Indol-1-yl-propyl)-1H-pyrazol-4-ylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

A solution of 1-[3-(2,3-dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine (200 mg, 0.83 mmol) in acetone (1.0 mL) was added dropwise to a suspension of MnO2 (275 mg, 3.17 mmol) in acetone (2.0 mL). The resulting dark reaction mixture was stirred at rt overnight, then filtered over celite, washed with acetone and the solvent was removed under reduced pressure to yield the title compound which was used without further purification in the next step. LC-MS conditions B: tR=0.51 min, [M+H]+=241.20.

Aufarbeitung

  1. customThe resulting dark reaction mixture
  2. filtrationfiltered over celite
  3. washwashed with acetone
  4. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8fe1a24413b2403da50ad27fd985e3ea
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303023B2

Notizen zur Reaktion

Wird geladen…