Ammonium Hydroxide → 5-Chloropyrazolo[1,5-a]pyrimidin-7-amine

HRID 624685

Reaktionsgleichung

Reaktionsgleichung von HRID 624685
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1.[OH-].[NH4+:13]>>[Cl:1][C:2]1[CH:7]=[C:6]([NH2:13])[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1

Komponenten

3

Edukt 2

HCID 14923Ammonium HydroxideHCID 110741545,7-Dichloropyrazolo[1,5-a]pyrimidine

Produkt 1

HCID 231319095-Chloropyrazolo[1,5-a]pyrimidin-7-amineAusbeute 88 %

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To the reaction flask, 5,7-dichloropyrazolo[1,5-a]pyrimidine (3 g, 16 mmol) was added along with ammonium hydroxide solution (48 mL). The heterogeneous reaction was refluxed at 85° C. for 12 hours. After cooling to room temperature, the mixture was filtered, washed with water, and dried under vacuum overnight. The product, 5-chloropyrazolo[1,5-a]pyrimidin-7-amine, was collected as an off-white solid in 88% yield. LCMS (M+1=169)

Aufarbeitung

  1. customThe heterogeneous reaction
  2. temperatureAfter cooling to room temperature
  3. filtrationthe mixture was filtered
  4. washwashed with water
  5. customdried under vacuum overnight
  6. customThe product, 5-chloropyrazolo[1,5-a]pyrimidin-7-amine, was collected as an off-white solid in 88% yield

Quellen und Nachweise

ORD-Eintrag
ord-da7ba9360b6e4438a5e2e7211cfe4289
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303033B2

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