Diisopropylethylamine → 5-Cyclopropyl-6-(2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid tert-butyl-methyl-amide

HRID 624864

Reaktionsgleichung

Reaktionsgleichung von HRID 624864
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:17]([OH:19])=O)=[N:8][C:9]=2[O:10][CH:11]([CH3:16])[C:12]([F:15])([F:14])[F:13])[CH2:3][CH2:2]1.[CH3:20][C:21]([NH:25][CH3:26])([CH3:24])[CH2:22]O.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>>[C:21]([N:25]([CH3:26])[C:17]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH:11]([CH3:16])[C:12]([F:13])([F:14])[F:15])[N:8]=1)=[O:19])([CH3:24])([CH3:22])[CH3:20]

Komponenten

5

Edukt 4

HCID 81531DiisopropylethylamineHCID 4227802-Methyl-2-methylamino-1-propanolHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 710874355-Cyclopropyl-6-(1,1,1-trifluoropropan-2-yloxy)picolinic acid

Produkt 1

HCID 902034975-Cyclopropyl-6-(2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid tert-butyl-methyl-amide

Versuchsvorschrift

In analogy to the procedure described in Example 47 b), 5-cyclopropyl-6-(1,1,1-trifluoropropan-2-yloxy)picolinic acid was reacted with 2-methyl-2-(methylamino)propan-1-ol (CAN 27646-80-6) in the presence of TBTU and DIEA to obtain the title compound as white solid; MS (EI): m/e=345.4 [MH+].

Quellen und Nachweise

ORD-Eintrag
ord-ca2b144c4292424ba088e09d26b67367
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09303012B2

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