HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4,4-Difluoro-L-prolinamide hydrochloride → (2S)-1-[6-(Cyclopropylmethoxy)-5-(1-hydroxycyclobutyl)pyridine-2-carbonyl]-4,4-difluoropyrrolidine-2-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4,4-Difluoro-L-prolinamide hydrochloride | HCID 45158909 | — |
| Edukt | 6-Cyclopropylmethoxy-5-(1-hydroxy-cyclobutyl)-pyridine-2-carboxylic acid | HCID 71087611 | — |
| Produkt | (2S)-1-[6-(Cyclopropylmethoxy)-5-(1-hydroxycyclobutyl)pyridine-2-carbonyl]-4,4-difluoropyrrolidine-2-carboxamide | HCID 76281331 | 26,6% |
Reaktionsschritte
In analogy to the procedure described in Example 127 e), 6-(cyclopropylmethoxy)-5-(1-hydroxycyclobutyl)pyridine-2-carboxylic acid (CAN 1415899-53-4, 15 mg, 57 μmol) was reacted with (S)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride (CAN 426844-51-1, 10.6 mg, 57 μmol) to give the title compound (6 mg, 21%) as light yellow oil, LC-MS (UV peak area, ESI) 100%, 396.1740 [MH+].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09303012B2 |
| Quelldatensatz | uspto-grants-2016_04 |
| ORD ID | ord-fc07b3a9ccd347fcb19d8361a8ca4171 |
| Quellennotiz | uspto-grants-2016_04 |