Morpholine → Cladrin

HRID 6280

Reaktionsgleichung

Reaktionsgleichung von HRID 6280
OC1C=C(O)C=C[C:3]=1[CH:9]([C:20]([CH:22]([C:33]1[CH:38]=CC(O)=CC=1O)[C:23]1C=CC(OC)=[C:25]([O:31]C)[CH:24]=1)=[O:21])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH3:19])[CH:11]=1.C([O:43]C([O-])[O-])C.N1CCOCC1>CN(C)C=O>[OH:31][C:25]1[CH:24]=[C:23]2[C:22]([C:20](=[O:21])[C:9]([C:10]3[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH3:19])[CH:11]=3)=[CH:3][O:43]2)=[CH:33][CH:38]=1

Komponenten

5

Edukt 3

HCID 8083MorpholineHCID 53630039EthylorthoformateHCID 1317181822,4-Dihydroxy-phenyl-(3',4'-dimethoxy-benzyl)-ketone

Produkt 1

HCID 5748605Cladrin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

14.4 g (0.05 mole) of 2,4-dihydroxy-phenyl-(3',4'-dimethoxy-benzyl)-ketone are reacted with 10.5 g (0.07 mole) ethyl-orthoformate in 10 ml of dimethyl-formamide in the presence of 1 ml morpholine. The reaction mixture is maintained at 80°-85° C., and in the second hour a solid precipitates. After 6 hours 1OO ml of chloroform are added to the mixture, the precipitated substance is filtered and dried. 7-hydroxy-3',4'-dimethoxy-isoflavone is obtained.

Aufarbeitung

  1. temperatureThe reaction mixture is maintained at 80°-85° C.
  2. customin the second hour a solid precipitates
  3. additionAfter 6 hours 1OO ml of chloroform are added to the mixture
  4. filtrationthe precipitated substance is filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d16c7c6433784192b16c37dc97ffc08b
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05247102

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