(E)-3-(4-benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester → Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate

HRID 62836

Reaktionsgleichung

Reaktionsgleichung von HRID 62836
[CH2:1]([O:3][C:4](=[O:23])/[CH:5]=[CH:6]/[C:7]1[CH:12]=[C:11]([F:13])[C:10]([O:14]CC2C=CC=CC=2)=[C:9]([F:22])[CH:8]=1)[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][CH2:6][C:7]1[CH:12]=[C:11]([F:13])[C:10]([OH:14])=[C:9]([F:22])[CH:8]=1)[CH3:2]

Komponenten

4

Edukt 1

HCID 90118234(E)-3-(4-benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester

Produkt 1

HCID 23136305Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoateAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

(E)-3-(4-Benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester (1.2 g, 3.77 mmol) obtained in Step C was dissolved in EtOH (20 mL), and 10% Pd/C (120 mg) was added to the solution. The mixture was stirred at room temperature under hydrogen atmosphere for 12 hours. The reactant was filtered by using celite and concentrated under reduced pressure to obtain the title compound (0.85 g, 98%).

Aufarbeitung

  1. filtrationThe reactant was filtered
  2. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-04b6b1677efc443d9d11e4b92fcd26ee
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447044B2

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