5,8,11,14,17-Eicosapentaenoic Acid → 5,8,11,14,17-Eicosapentaenoyl chloride

HRID 628785Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 628785
[C:1]([OH:22])(=O)[CH2:2][CH2:3][CH2:4][CH:5]=[CH:6][CH2:7][CH:8]=[CH:9][CH2:10][CH:11]=[CH:12][CH2:13][CH:14]=[CH:15][CH2:16][CH:17]=[CH:18][CH2:19][CH3:20].C(Cl)(=O)C([Cl:26])=O>C(Cl)(Cl)Cl>[C:1]([Cl:26])(=[O:22])[CH2:2][CH2:3][CH2:4][CH:5]=[CH:6][CH2:7][CH:8]=[CH:9][CH2:10][CH:11]=[CH:12][CH2:13][CH:14]=[CH:15][CH2:16][CH:17]=[CH:18][CH2:19][CH3:20]

Komponenten

4

Edukt 2

HCID 32095,8,11,14,17-Eicosapentaenoic AcidHCID 65578Oxalyl chloride

Produkt 1

HCID 540845485,8,11,14,17-Eicosapentaenoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 605 mg of 5,8,11,14,17-eicosapentaenic acid 6 in 6 ml of dry chloroform was added 0.25 ml of oxalyl chloride under argon at room temperature. The mixture was reacted for 2 hours. From the reaction mixture were removed the chloroform and the remaining oxalyl chloride by distillation under reduced pressure to give 5,8,11,14,17-eicosapentaenoyl chloride 7, which was then directly used for the next step.

Aufarbeitung

  1. customThe mixture was reacted for 2 hours
  2. customFrom the reaction mixture were removed the chloroform
  3. distillationthe remaining oxalyl chloride by distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-29e4fde8f39248058564ab4d8e68f5f9
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315461B2

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