Morpholine → HCID 86673493, Verbindung

HRID 629006Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 629006
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([O:9][CH2:10][CH3:11])=[CH:4][N:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[NH4+].[Cl-]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[N:7]=[C:6]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]([O:9][CH2:10][CH3:11])=[CH:4][N:3]=1

Komponenten

5

Edukt 3

HCID 8083MorpholineHCID 25517Ammonium ChlorideHCID 155652702,4-Dichloro-5-ethoxypyrimidine

Produkt 1

HCID 86673493HCID 86673493, VerbindungAusbeute 73,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel2×

Versuchsvorschrift

2,4-dichloro-5-ethoxy-pyrimidin (2.83 g, 1.0 eq) was stirred in toluene (20 ml) and a solution of morpholine (1.93 ml, 1.5 eq) in toluene (20 ml) was added dropwise at −10˜0° C. After stirring the resulting solution overnight at r.t., NH4Cl(aq) was added to the solution and the solution was extracted with EA. The combined organic layers were washed with brine, dried and evaporated in vacuo. A product was obtained as a white solid (2.7 g, 73.5%).

Aufarbeitung

  1. extractionthe solution was extracted with EA
  2. washThe combined organic layers were washed with brine
  3. customdried
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d184133309004e728c3ac474b799dce2
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315491B2

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