Ammonia → HCID 86702436, Verbindung
Reaktionsgleichung
Br[C:2]1[CH:3]=[C:4]([F:12])[CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[CH3:11].[NH3:13]>O>[CH3:11][C:7]1[C:6]2[C:10](=[C:2]([NH2:13])[CH:3]=[C:4]([F:12])[CH:5]=2)[NH:9][CH:8]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 170 °C
Versuchsvorschrift
A mixture of 7-bromo-5-fluoro-3-methyl-indole (2.5 g), Cu (0.77 g), CuBr (1.57 g) and NH3 (30 ml of a 33% aqueous solution) was heated in an autoclave for 2 h at 170° C. The mixture was diluted with water and extracted with EtOAc. The organic phase was dried and the solvent removed to give 3-methyl-5-fluoro-7-amino-indole as an oil which was used without further purification. UPLC/MS found for C9H9FN2 as (M+H)+165.2
Aufarbeitung
- extractionextracted with EtOAc
- customThe organic phase was dried
- customthe solvent removed
Quellen und Nachweise
- ORD-Eintrag
- ord-1adbe73d95c448949199a1d1eb2e4a3b
- Quelldatensatz
- uspto-grants-2016_04
- Patentnummer
- US09315500B2
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