Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 629637Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 629637
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

Produkt 1

HCID 31128494-Morpholinobut-2-YN-1-OL

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel2×

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To a mixture of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The mixture was stirred at 85° C. for three hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the title compound.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

Quellen und Nachweise

ORD-Eintrag
ord-288300dd95a340d1afcedb61e552b5e3
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315488B2

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