Dichloromethane → 4-Bromo-2-(bromomethyl)-1-chlorobenzene

HRID 630039

Reaktionsgleichung

Reaktionsgleichung von HRID 630039
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([CH3:9])[CH:3]=1.[Br:10]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.ClCCl>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([CH2:9][Br:10])[CH:3]=1

Komponenten

6

Edukt 4

HCID 6344DichloromethaneHCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 6098995-Bromo-2-chlorotoluene

Produkt 1

HCID 115582804-Bromo-2-(bromomethyl)-1-chlorobenzeneAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

A mixture of 4-bromo-1-chloro-2-methylbenzene (5.0 g, 24.0 mmol), N-bromosuccinimide (4.4 g, 25.0 mmol), and benzoyl peroxide (700 mg, 2.9 mmol) in anhydrous carbon tetrachloride (85 mL) was stirred at reflux for 4 hours. Dichloromethane (50 mL) was added. The mixture was extracted with 1 N NaOH (1×150 mL) and brine (1×150 mL). The organic extract was recovered, dried over MgSO4, filtered, evaporated, and dried in vacuo. The crude product was purified by flash chromatography (0-5% EtOAc/hexanes), affording 4-bromo-2-(bromomethyl)-1-chlorobenzene (4.76 g, 70% yield). The product was used without further purification.

Aufarbeitung

  1. temperatureat reflux for 4 hours
  2. extractionThe mixture was extracted with 1 N NaOH (1×150 mL) and brine (1×150 mL)
  3. extractionThe organic extract
  4. customwas recovered
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. customevaporated
  8. customdried in vacuo
  9. customThe crude product was purified by flash chromatography (0-5% EtOAc/hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-ed3849c3768241ef9ae0d89b7e3ab53d
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09315521B2

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