Phenyl chloroformate → phenyl 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ylcarbamate
Reaktionsgleichung
[CH3:1][N:2]1[C:6]([NH2:7])=[CH:5][C:4]([C:8]([F:11])([F:10])[F:9])=[N:3]1.Cl[C:13]([O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:14]>>[CH3:1][N:2]1[C:6]([NH:7][C:13](=[O:14])[O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:5][C:4]([C:8]([F:9])([F:10])[F:11])=[N:3]1Komponenten
3
Versuchsvorschrift
Using the procedure described in Example 161C, 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-amine (1.70 g, 10.3 mmol) and phenyl chloroformate (1.88 g, 12 mmol) were reacted to afford phenyl 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-ylcarbamate as solid (0.760 g, 26%). LC-MS (ESI) m/z 286 (M+H)+.
Aufarbeitung
- customwere reacted