L-Leucinol → 5-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide

HRID 632363

Reaktionsgleichung

Reaktionsgleichung von HRID 632363
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:16]([OH:18])=O)=[N:8][C:9]=2[O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH2:3][CH2:2]1.[NH2:19][C@H:20]([CH2:25][OH:26])[CH2:21][CH:22]([CH3:24])[CH3:23]>>[OH:26][CH2:25][C@@H:20]([NH:19][C:16]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])[N:8]=1)=[O:18])[CH2:21][CH:22]([CH3:24])[CH3:23]

Komponenten

3

Edukt 2

HCID 111307L-LeucinolHCID 710876495-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Produkt 1

HCID 711132755-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 280c, using 5-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 301a) and L-leucinol (CAN 17016-87-4) as starting materials, MS (EI): m/e=361.3 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-32f12e51eca14e1996937fca65265b93
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321727B2

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