Dichloromethane → HCID 86730673, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([O:11][C:12]3[CH:13]=[CH:14][C:15](C=O)=[N:16][CH:17]=3)=[C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[S:8][C:7]=2[CH:28]=1.C1(P(C2C=CC=CC=2)(C2C=CC=CC=2)=[CH:36][C:37]([O:39][CH3:40])=[O:38])C=CC=CC=1.[CH2:53](Cl)Cl>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([O:11][C:12]3[CH:13]=[CH:14][C:15](/[CH:53]=[CH:36]/[C:37]([O:39][CH3:40])=[O:38])=[N:16][CH:17]=3)=[C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[S:8][C:7]=2[CH:28]=1Komponenten
Versuchsvorschrift
To a solution of 5-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)picolinaldehyde (0.265 g, 0.68 mmol) in DCM (3.38 mL) at 0° C. was added methyl 2-(triphenylphosphoranylidene)acetate (0.543 g, 1.63 mmol) and the reaction was stirred at room temperature for 18 h. Upon completion the mixture was concentrated in vacuo to afford crude material which was purified by column chromatography (SiO2, 0-25% EtOAc/heptanes) to afford (E)-methyl 3-(5-((6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)oxy)pyridin-2-yl)acrylate (96 mg, 0.22 mmol, 32% yield). 1H NMR (400 MHz, CDCl3) δ ppm=3.70-3.75 (m, 6H), 3.79-3.83 (m, 3 H), 6.70 (d, J=15.66 Hz, 1 H), 6.77-6.88 (m, 3 H), 7.02 (dd, J=8.59, 3.03 Hz, 1 H), 7.17 (s, 1 H), 7.18-7.22 (m, 2 H), 7.48-7.59 (m, 3 H), 8.42 (d, J=2.53 Hz, 1 H). LC/MS (m/z, MH+): 448.3.
Aufarbeitung
- concentrationUpon completion the mixture was concentrated in vacuo
- customto afford crude material which
- customwas purified by column chromatography (SiO2, 0-25% EtOAc/heptanes)
Quellen und Nachweise
- ORD-Eintrag
- ord-842b15bde121478da673379b2bbada07
- Quelldatensatz
- uspto-grants-2016_04
- Patentnummer
- US09321746B2
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