Butyl bromide → HCID 178418677, Verbindung

HRID 6332

Reaktionsgleichung

Reaktionsgleichung von HRID 6332
[F:1][C:2]1[C:7]([F:8])=[C:6]([O:9][CH2:10][C@H:11]2[CH2:16][CH2:15][C@H:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:13][CH2:12]2)[CH:5]=[CH:4][C:3]=1[OH:22].[CH2:23](Br)[CH2:24][CH2:25][CH3:26].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:23]([O:22][C:3]1[CH:4]=[CH:5][C:6]([O:9][CH2:10][C@H:11]2[CH2:16][CH2:15][C@H:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:13][CH2:12]2)=[C:7]([F:8])[C:2]=1[F:1])[CH2:24][CH2:25][CH3:26]

Komponenten

5

Edukt 3

HCID 8002Butyl bromideHCID 11430Potassium CarbonateHCID 178418594HCID 178418594, Verbindung

Produkt 1

HCID 178418677HCID 178418677, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

0.1 mol of 2,3-difluoro-4-(trans-4-pentylcyclohexyl)methoxyphenol, 0.11 mol of butyl bromide and 0.11 mol of potassium carbonate are heated for 16 hours at 100° in 100 ml of dimethylformamide (DMF). After cooling, the inorganic salts are filtered off with suction, the filtrate is concentrated, and water is added. 1-butyloxy-2,3-difluoro-4-(trans-4-pentylcyclohexyl)methoxybenzene is obtained by extraction with dichloromethane.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe inorganic salts are filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. additionwater is added

Quellen und Nachweise

ORD-Eintrag
ord-709fc48404a84ef09737b5887db2472e
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05248447

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