HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cyclohexanemethanol → 2-(Cyclohexylmethoxy)pyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cyclohexanemethanol | HCID 7507 | — |
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 2-Bromopyrimidine | HCID 78345 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-(Cyclohexylmethoxy)pyrimidine | HCID 86694667 | — |
Reaktionsschritte
NaH (1.1 equivalent) is added to an equimolar mixture of 2-bromopyrimidine and cyclohexylmethanol in THF. The reaction mixture is stirred at +60° C. for 18 hours, cooled to room temperature, partitioned between H2O and ethyl acetate. Organic portion is separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 2-(cyclohexylmethoxy)pyrimidine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09447078B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-08bcb063c6f745de8323dde4cf803480 |
| Quellennotiz | uspto-grants-2016_09 |