Sodium methanesulfinate → 3-Bromo-2-chloro-5-((methylsulfonyl)methyl)pyridine

HRID 633593Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 633593
[CH3:1][S:2]([O-:4])=[O:3].[Na+].[Br:6][C:7]1[C:8]([Cl:15])=[N:9][CH:10]=[C:11]([CH2:13]Br)[CH:12]=1>CN(C)C=O.O>[Br:6][C:7]1[C:8]([Cl:15])=[N:9][CH:10]=[C:11]([CH2:13][S:2]([CH3:1])(=[O:4])=[O:3])[CH:12]=1

Komponenten

5

Edukt 2

HCID 2733271Sodium methanesulfinateHCID 848198723-Bromo-5-(bromomethyl)-2-chloropyridine

Produkt 1

HCID 904175713-Bromo-2-chloro-5-((methylsulfonyl)methyl)pyridineAusbeute 84,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

Sodium methanesulfinate (0.748 g, 7.32 mmol) and the product from Example 143A (1.9 g, 6.66 mmol) were combined in N,N-dimethylformamide (4.44 mL) and heated at 65° C. for 1 hour. The reaction mixture was cooled and diluted with 200 mL of cold water producing a precipitate that was collected by filtration and dried to constant mass affording the title compound (1.6 g, 84%).

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. filtrationwas collected by filtration
  3. customdried to constant mass

Quellen und Nachweise

ORD-Eintrag
ord-29d94dafc13c4b9a8f9e4c87248892b3
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321764B2

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