1,2-Benzenedicarbonitrile, 4-nitro- → 1,2-Benzenedicarbonitrile, 4-amino-

HRID 634574

Reaktionsgleichung

Reaktionsgleichung von HRID 634574
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7](=[CH:10][CH:11]=1)[C:8]#[N:9])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7](=[CH:10][CH:11]=1)[C:8]#[N:9]

Komponenten

4

Edukt 1

HCID 974431,2-Benzenedicarbonitrile, 4-nitro-

Produkt 1

HCID 925291,2-Benzenedicarbonitrile, 4-amino-Ausbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A portion of 4-nitrophthalonitrile (5.15 g, 29.8 mmole) was dissolved in 125 mL methanol in a hydrogenation flask. The catalyst, 10% Pd/C (515 mg), was added to the mixture which was then flushed with H2 and stirred under 50 psi of H2 for 1 hour. The catalyst was removed by filtration and the solvent was distilled off under vacuum. The desired 4-aminophthalonitrile was obtained in 86% yield (3.66 g).

Aufarbeitung

  1. customwas then flushed with H2
  2. customThe catalyst was removed by filtration
  3. distillationthe solvent was distilled off under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-8c820d56c656418591e22241ec76bd51
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06183727B2

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