Hydrogen Bromide → N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide

HRID 634909Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 634909
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13]C)[CH:11]=2)[C:6]([CH3:15])=[CH:5][C:4]1([CH3:17])[CH3:16])[CH3:2].[BrH:18]>C(O)(=O)C>[BrH:18].[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([OH:13])[CH:11]=2)[C:6]([CH3:15])=[CH:5][C:4]1([CH3:16])[CH3:17])[CH3:2]

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 154511021-Ethyl-7-methoxy-2,2,4-trimethyl-1,2-dihydroquinoline

Produkt 1

HCID 21260952N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromideAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

60 g (0.25 mol) N-ethyl-2,2,4-trimethyl-7-methoxy-1,2-dihydroquinoline was dissolved in 150 ml glacial acetic acid and 150 ml hydrobromic acid was added. The solution was refluxed for 24 h. The cooled solution was stirred in an ice/methanol bath. Subsequently the precipitate was filtered and washed several times with acetone. Colourless crystals were formed in a yield of 85%.

Aufarbeitung

  1. temperatureThe solution was refluxed for 24 h
  2. filtrationSubsequently the precipitate was filtered
  3. washwashed several times with acetone
  4. customColourless crystals were formed in a yield of 85%

Quellen und Nachweise

ORD-Eintrag
ord-0e6936646cc4469fb58c7b1693219c31
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06184379B2

Notizen zur Reaktion

Wird geladen…