2-Bromobiphenyl → 9-(2-Biphenylyl)-2,7-dicarbethoxy-9-fluorenol

HRID 635126

Reaktionsgleichung

Reaktionsgleichung von HRID 635126
[Mg].Br[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[C:15]([C:20]1[CH:32]=[CH:31][C:30]2[C:29]3[C:24](=[CH:25][C:26]([C:33]([O:35][CH2:36][CH3:37])=[O:34])=[CH:27][CH:28]=3)[C:23](=[O:38])[C:22]=2[CH:21]=1)([O:17][CH2:18][CH3:19])=[O:16]>C(OCC)C>[C:4]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:23]1([OH:38])[C:24]2[CH:25]=[C:26]([C:33]([O:35][CH2:36][CH3:37])=[O:34])[CH:27]=[CH:28][C:29]=2[C:30]2[C:22]1=[CH:21][C:20]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:32][CH:31]=2

Komponenten

5

Edukt 3

HCID 163292-BromobiphenylHCID 5462224MagnesiumHCID 149248402,7-Dicarbethoxy-9-fluorenone

Produkt 1

HCID 220160409-(2-Biphenylyl)-2,7-dicarbethoxy-9-fluorenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

A Grignard reagent prepared from 0.97 g (40 mmol) of magnesium turnings and 9.32 g (6.8 ml, 40 mmol) of 2-bromobiphenyl in 50 ml of dry diethyl ether was added dropwise to a boiling solution of 13 g (40 mmol) of 2,7-dicarbethoxy-9-fluorenone in 100 ml of dry diethyl ether over the course of 2 h. When addition was complete, the mixture was boiled for a further 3 hours. After cooling overnight, the precipitate formed was filtered off with suction and washed with cold ether. The magnesium complex was filtered off with suction and hydrolyzed in a solution of 15 g of ammonium chloride in 250 ml of iced water. After 1 h, the 9-(2-biphenylyl)-2,7-dicarbethoxy-9-fluorenol which had formed was filtered off with suction, washed with water and sucked dry. For the ring-closure reaction, the dried fluorenol was boiled for 6 hours in 100 ml of glacial acetic acid, following the addition of 3 drops of conc. HCl. The mixture was left to crystallize overnight, and the product which had formed was filtered off with suction and washed with glacial acetic acid and water.

Aufarbeitung

  1. additionWhen addition
  2. temperatureAfter cooling overnight
  3. customthe precipitate formed
  4. filtrationwas filtered off with suction
  5. washwashed with cold ether
  6. filtrationThe magnesium complex was filtered off with suction and hydrolyzed in a solution of 15 g of ammonium chloride in 250 ml of iced water
  7. waitAfter 1 h

Quellen und Nachweise

ORD-Eintrag
ord-072d6cd14234477b8a6bed3c53d809e4
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06187224B1

Verknüpfte Notizen

Wird geladen…