HCID 21256487, Verbindung → HCID 21256443, Verbindung

Reaktionsgleichung

[CH3:1][C:2]1[CH:15]=[CH:14][C:5]2[N:6]3[C:11]([CH2:12][OH:13])=[CH:10][N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1>C1(C)C=CC=CC=1.O1CCOCC1.O=[Mn]=O>[CH3:1][C:2]1[CH:15]=[CH:14][C:5]2[N:6]3[C:11]([CH:12]=[O:13])=[CH:10][N:9]=[C:7]3[S:8][C:4]=2[CH:3]=1

Komponenten

Versuchsvorschrift

A suspension of 7-Methyl-imidazo[2,1-b]benzothiazole-3-methanol (Formula K-2) (0.82 g) in hot toluene (100 mL) was diluted with dioxane (10 mL) to effect dissolution of 7-Methyl-imidazo [2,1b]benzothiazole-3-methanol (Formula K-2). The solution was treated with activated MnO2 (1.64 g) and azeotropically distilled for 1.25 hours. The suspension was filtered, the cake was washed with hot ethyl acetate, and the filtrate was evaporated to a crystalline solid (0.69 g). Crystallization from isopropanol gave pure 7-Methyl-imidazo[2,1-b]benzothiazole-3-carboxaldehyde (Formula K-3) (0.56 g), m.p. 170-171°.