HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 4-(4-Fluorophenyl)-2-hydroxy-6-methylpyrimidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Urea | HCID 1176 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 1-(4-Fluoro-phenyl)-butane-1,3-dione | HCID 432655 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | 4-(4-Fluorophenyl)-2-hydroxy-6-methylpyrimidine | HCID 178422714 | 46,9% |
Reaktionsschritte
A mixture of 5 g of 4-fluorobenzoylacetone, 1.66 g of urea, 25 ml of ethanol, and 3.8 ml of concentrated hydrochloric acid was refluxed for 20 hours. This reaction mixture was cooled, poured into iced water, made basic with aqueous solution of potassium carbonate, and neutralized with acetic acid. The crystals that separated out were collected by filtration, washed with isopropyl ether, and dried to provide 2.65 g of pale yellow crystals. m.p. 265-268° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06191149B1 |
| Quelldatensatz | uspto-grants-2001_02 |
| ORD ID | ord-0c87bdaf0e5c4bbc85733afaad7cc70b |
| Quellennotiz | uspto-grants-2001_02 |