Hydrochloric Acid → 4-(4-Fluorophenyl)-2-hydroxy-6-methylpyrimidine

HRID 635891노트

반응식

HRID 635891 반응식
[F:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([CH2:8][C:9](=O)[CH3:10])=O)=[CH:4][CH:3]=1.[NH2:14][C:15]([NH2:17])=[O:16].Cl.C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C.O.C(O)C>[F:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]2[CH:8]=[C:9]([CH3:10])[N:17]=[C:15]([OH:16])[N:14]=2)=[CH:4][CH:3]=1

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 1176UreaHCID 11430Potassium CarbonateHCID 4326551-(4-Fluoro-phenyl)-butane-1,3-dione

생성물 1

HCID 1784227144-(4-Fluorophenyl)-2-hydroxy-6-methylpyrimidine수율 46.9%

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture of 5 g of 4-fluorobenzoylacetone, 1.66 g of urea, 25 ml of ethanol, and 3.8 ml of concentrated hydrochloric acid was refluxed for 20 hours. This reaction mixture was cooled, poured into iced water, made basic with aqueous solution of potassium carbonate, and neutralized with acetic acid. The crystals that separated out were collected by filtration, washed with isopropyl ether, and dried to provide 2.65 g of pale yellow crystals. m.p. 265-268° C.

후처리

  1. temperaturewas refluxed for 20 hours
  2. temperatureThis reaction mixture was cooled
  3. customThe crystals that separated out
  4. filtrationwere collected by filtration
  5. washwashed with isopropyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-0c87bdaf0e5c4bbc85733afaad7cc70b
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06191149B1

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