反应详情

A mixture of 5 g of 4-fluorobenzoylacetone, 1.66 g of urea, 25 ml of ethanol, and 3.8 ml of concentrated hydrochloric acid was refluxed for 20 hours. This reaction mixture was cooled, poured into iced water, made basic with aqueous solution of potassium carbonate, and neutralized with acetic acid. The crystals that separated out were collected by filtration, washed with isopropyl ether, and dried to provide 2.65 g of pale yellow crystals. m.p. 265-268° C.

1. temperaturewas refluxed for 20 hours
2. temperatureThis reaction mixture was cooled
3. customThe crystals that separated out
4. filtrationwere collected by filtration
5. washwashed with isopropyl ether
6. customdried