Water → 6-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amine

HRID 63605

Reaktionsgleichung

Reaktionsgleichung von HRID 63605
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1.[CH2:11]([NH2:14])[C:12]#[CH:13].O>C(#N)C>[Cl:8][C:6]1[N:5]=[C:4]([S:9][CH3:10])[N:3]=[C:2]([NH:14][CH2:11][C:12]#[CH:13])[CH:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 805314,6-Dichloro-2-(methylthio)pyrimidineHCID 239041Propargylamine

Produkt 1

HCID 903036916-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amineAusbeute 99,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 1.00 g (5.13 mmol) of 4,6-dichloro-2-(methylthio)pyrimidine and 0.7 ml (10.3 mmol) of propargylamine in 10 ml of acetonitrile was stirred for 12 hours at 60° C. The reaction solution was poured onto cold water. Then, the formed precipitate was filtered, washed several times with cold water and dried. 1.09 g of a light yellow solid were obtained.

Aufarbeitung

  1. filtrationThen, the formed precipitate was filtered
  2. washwashed several times with cold water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-01225f880448429ca0699b60ca00ba14
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447095B2

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