Formic Acid → HCID 118597990, Verbindung

HRID 63643

Reaktionsgleichung

Reaktionsgleichung von HRID 63643
[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[CH2:3][O:2]1.[CH:11](O)=[O:12]>>[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][CH:11]=[O:12])=[CH:9][C:4]=2[CH2:3][O:2]1

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 124453391,3-Dihydro-2-benzofuran-5-amine

Produkt 1

HCID 118597990HCID 118597990, VerbindungAusbeute 69 %

Versuchsvorschrift

1,3-Dihydro-2-benzofuran-5-amine (300 mg, 2.2 mmol) was added to HCOOH (10 mL), and the reaction was stirred at reflux overnight. The reaction was concentrated, basified to pH=8 with sat Na2CO3, and extracted with EtOAc. Organics were washed with brine, dried (Na2SO4), and concentrated to give 250 mg (69%) of N-(1,3-dihydro-2-benzofuran-5-yl)formamide as a yellow oil.

Aufarbeitung

  1. temperatureat reflux overnight
  2. concentrationThe reaction was concentrated
  3. extractionextracted with EtOAc
  4. washOrganics were washed with brine
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-7535fa64e1b44f0aa936eef954ce8d4b
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447046B2

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