Malonic Acid → 4-[(E)-2-(4-pyridyl)vinyl]cinnamic acid

HRID 636516Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 636516
[N:1]1[CH:6]=[CH:5][C:4](/[CH:7]=[CH:8]/[C:9]2[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=2)=[CH:3][CH:2]=1.C(O)(=O)[CH2:18][C:19]([OH:21])=[O:20].C(OCC)(=O)C>N1C=CC=CC=1.C(O)C>[N:1]1[CH:6]=[CH:5][C:4](/[CH:7]=[CH:8]/[C:9]2[CH:16]=[CH:15][C:12]([CH:13]=[CH:18][C:19]([OH:21])=[O:20])=[CH:11][CH:10]=2)=[CH:3][CH:2]=1

Komponenten

6

Edukt 3

HCID 867Malonic AcidHCID 8857Ethyl AcetateHCID 53747304-(2-(4-Formylphenyl)ethenyl)pyridine

Produkt 1

HCID 702455054-[(E)-2-(4-pyridyl)vinyl]cinnamic acidAusbeute 46,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a solution of 4-[(E)-2-(4-pyridyl)vinyl]benzaldehyde (50 mg) in pyridine (0.025 ml) and ethanol (0.075 ml) was added malonic acid (27.4 mg), and the mixture was refluxed for 7 hours. After cooling, ethyl acetate was added thereto, the resulting precipitates were collected by filtration to give 4-[(E)-2-(4-pyridyl)vinyl]cinnamic acid (28 mg).

Aufarbeitung

  1. temperaturethe mixture was refluxed for 7 hours
  2. temperatureAfter cooling
  3. customthe resulting precipitates
  4. filtrationwere collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-d6f41240b6ef49eb96bac0acca6767dc
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06194396B1

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