1-(4-Nitrophenyl)azetidine → Benzenamine,4-(1-azetidinyl)-

HRID 63664Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 63664
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O>CCO.[Pd]>[N:10]1([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[CH2:11][CH2:12][CH2:13]1

Komponenten

4

Edukt 1

HCID 5917181-(4-Nitrophenyl)azetidine

Produkt 1

HCID 45078992Benzenamine,4-(1-azetidinyl)-Ausbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

10% Pd/C (70 mg) was added to a solution of 1-(4-nitrophenyl)azetidine (0.7 g, 3.9 mmol) in EtOH (15 mL) at r.t. under N2. After stirring under 50 psi H2 overnight, the reaction mixture was filtered through Celite and concentrated to give 580 mg (99%) of the title compound as a brown oil. [M+H] Calc'd for C9H12N2, 149. Found, 149.

Aufarbeitung

  1. filtrationthe reaction mixture was filtered through Celite
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-5ba19c232b134171a55137719f1bebac
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447046B2

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