Ammonium Chloride → 1,3-Thiazole-2-carboximidamide hydrochloride

HRID 63670Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 63670
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]#[N:7].C[O-].[Na+].[Cl-:11].[NH4+:12]>CO>[ClH:11].[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]([NH2:12])=[NH:7]

Komponenten

5

Edukt 3

HCID 25517Ammonium ChlorideHCID 10942334Sodium MethoxideHCID 151114801,3-Thiazole-2-carbonitrile

Produkt 1

HCID 186795841,3-Thiazole-2-carboximidamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To a stirred solution of thiazole-2-carbonitrile (1.5 g, 14 mmol) in 5 mL of dry MeOH was added dropwise a solution of sodium methoxide (0.74 g, 14 mmol) in 10 mL of dry methanol. The reaction mixture was stirred at room temperature until the disappearance of starting material which was checked by LC/MS. After that, ammonium chloride (1.5 g, 28 mmol) was added in one portion and the reaction mixture was stirred overnight. The undissolved material was removed by filtration and the filtrate was concentrated to afford thiazole-2-carboxamidine hydrochloride (Compound A1) as a grey solid which was used directly in the next step without further purification. MS: calc'd 128 (MH+), measured 128 (MH+).

Aufarbeitung

  1. stirringthe reaction mixture was stirred overnight
  2. customThe undissolved material was removed by filtration
  3. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-24aef6e0a5a042c68a0a6ee416267029
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447086B2

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