Water → 2-Methyl-2-nitro-1-(methoxymethoxy)propane

HRID 636736Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 636736
[CH3:1][C:2]([N+:6]([O-:8])=[O:7])([CH3:5])[CH2:3][OH:4].[Li+].[Br-].O.C1(C)C=CC(S(O)(=O)=O)=CC=1.O.[CH3:24][O:25][CH2:26]OC>>[CH3:1][C:2]([N+:6]([O-:8])=[O:7])([CH3:5])[CH2:3][O:4][CH2:24][O:25][CH3:26]

Komponenten

6

Edukt 5

HCID 962WaterHCID 64422-Methyl-2-nitro-1-propanolHCID 8020DimethoxymethaneHCID 82050Lithium BromideHCID 521998p-Toluenesulfonic acid monohydrate

Produkt 1

HCID 212556992-Methyl-2-nitro-1-(methoxymethoxy)propaneAusbeute 76 %

Versuchsvorschrift

To a solution of 2-methyl-2-nitro-1-propanol (366.8 mg, 3.08 mmol) and LiBr (60.8 mg, 0.700 mmol) in dimethoxymethane (5 ml) was added p-toluenesulfonic acid hydrate (56.3 mg, 0.296 mmol) and stirred for 24 hours. The mixture was added to water and extracted three times with ethyl acetate and dried over MgSO4. The mixture was concentrated and purified by silica gel chromatography (hexane/ether=4/1) to give the title compound (382.7 mg; 76%).

Aufarbeitung

  1. extractionextracted three times with ethyl acetate
  2. dry with materialdried over MgSO4
  3. concentrationThe mixture was concentrated
  4. custompurified by silica gel chromatography (hexane/ether=4/1)

Quellen und Nachweise

ORD-Eintrag
ord-65625b631df84f3c80df010961eff1d7
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06194461B1

Notizen zur Reaktion

Wird geladen…