Water → (2-Fluoro-4-methoxyphenyl)methanol

HRID 636749Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 636749
[H-].[H-].[H-].[H-].[Li+].[Al+3].[F:7][C:8]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:9]=1[C:10](OC)=[O:11].O>C1COCC1>[F:7][C:8]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:9]=1[CH2:10][OH:11]

Komponenten

5

Edukt 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 21255685Methyl 2-fluoro-4-methoxybenzoate

Produkt 1

HCID 593638(2-Fluoro-4-methoxyphenyl)methanolAusbeute 104 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel3×

Versuchsvorschrift

To a suspension of LiAlH4 (71.6 mg, 1.89 mmol) in THF (3 ml) was added dropwise a solution of methyl 2-fluoro-4-methoxybenzoate (273.3 mg, 1.48 mmol) in THF (3 ml). The mixture was stirred for 0.5 hours. To the mixture was added dropwise aqueous THF followed by water. The mixture was extracted three times with ethyl acetate and dried over MgSO4. The solvent was evaporated to give the crude title compound (240.4 mg; >99%).

Aufarbeitung

  1. extractionThe mixture was extracted three times with ethyl acetate
  2. dry with materialdried over MgSO4
  3. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-4436b359decf49398fa62d0241d72553
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06194461B1

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