Water → (R)-2-Phenylbutan-1-ol

Temperatur

60 °C

To a suspension of 2.3 gm of LAH (60.6 mmol) in 70 mL of THF was slowly added a solution of 5 gm of (R)-(−)-2-phenylbutyric acid (30.45 mmol, Aldrich) in 30 mL of THF. The reaction mixture was heated to 60° C. for 3 hr. The reaction was cooled to 0° C. and to it was successively added 2 mL of water, 2 mL of 1N KOH and 2 mL of water. The aluminum salts were removed by filtration and washed with 100 mL of ethylacetate. The filtrate was dried over MgSO4, filtered and concentrated to give the title compound which was used without purification.

1. temperatureThe reaction was cooled to 0° C. and to it
2. customThe aluminum salts were removed by filtration
3. washwashed with 100 mL of ethylacetate
4. dry with materialThe filtrate was dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated

ORD-Eintrag

ord-b916815584f14b6080ddb315ae39c57b

Quelldatensatz

uspto-grants-2001_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06194458B1