Hydrochloric Acid → 2-Methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acid

HRID 637163Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 637163
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([S:18]([CH3:21])(=[O:20])=[O:19])=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].CO.[OH-].[Na+].Cl>ClCCl.O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([S:18]([CH3:21])(=[O:20])=[O:19])=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 18464688methyl 2-methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoate

Produkt 1

HCID 184644382-Methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Combine methyl 2-methoxy-5-(5-methylsulfonyl-1H-tetrazol-1-yl)benzoate (5 mmol), methanol (10 mL), and a 1 M aqueous sodium hydroxide solution (6 mL, 6.0 mmol). After 18 hours, evaporate in vacuo to give a residue. Combine the residue, water (5 mL) and acidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (6.5 mL). Evaporate in vacuo to give a residue. Combine the residue and dichloromethane and stir. Decant and add dichloromethane and stir. Decant and combine with the first decantate. Dry over Na2SO4, filter, and concentrate in vacuo to give the title compound.

Aufarbeitung

  1. customevaporate in vacuo
  2. customto give a residue
  3. customEvaporate in vacuo
  4. customto give a residue
  5. customDecant
  6. additionadd dichloromethane
  7. stirringstir
  8. customDecant
  9. dry with materialDry over Na2SO4
  10. filtrationfilter
  11. concentrationconcentrate in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fe8157d88837429889f2a89538ee330f
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06194406B1

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