Ammonia → N-[4-Chloro-6-(2,3-xylidino)-2-pyrimidinyl]-aminoacetic acid amide
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[C:10]=2[CH3:16])[N:5]=[C:4]([NH:17][CH2:18][C:19](OCC)=O)[N:3]=1.[NH3:24].[OH2:25]>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[C:10]=2[CH3:16])[N:5]=[C:4]([NH:17][C:18](=[O:25])[CH2:19][NH2:24])[N:3]=1Komponenten
4
Reaktionsbedingungen
- Temperatur
- 120 °C
Versuchsvorschrift
A suspension of ethyl 4-chloro-6-(2,3-xylidino)-2-pyrimidinylaminoacetate (500 mg) in a 10% ammonia ethanolic solution (5 ml) is heated for 20 hours at 120° C. in closed vessel. The mixture is then diluted with water (10 ml) and filtered, yielding 300 mg of the desired amide (I, 3). By the same method the amides of the following acids have been prepared: