N-methylpiperidine-4-carboxamide → 1-[6-Chloro-2-(4-fluorophenyl)-4-quinolinyl]-N-methyl-4-piperidinecarboxamide

HRID 638293

Reaktionsgleichung

Reaktionsgleichung von HRID 638293
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:3]=1.[CH3:20][NH:21][C:22](=[O:29])[CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>N1C=CC=CC=1.O>[Cl:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[C:4]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[CH:3]=[C:2]2[N:26]1[CH2:27][CH2:28][CH:23]([C:22]([NH:21][CH3:20])=[O:29])[CH2:24][CH2:25]1

Komponenten

4

Edukt 2

HCID 2760460N-methylpiperidine-4-carboxamideHCID 136039014,6-Dichloro-2-(4-fluorophenyl)quinoline

Produkt 1

HCID 136039271-[6-Chloro-2-(4-fluorophenyl)-4-quinolinyl]-N-methyl-4-piperidinecarboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 66926435Pyridine waterLösungsmittel

Versuchsvorschrift

The named compound was made in a manner analogous to that of Example 4(c) using 4,6-dichloro-2-(4-fluorophenyl)quinoline, prepared as in Example 20, and N-methylisonipecotamide as starting materials. It was obtained as off-white needles, mp 260°-265° dec on recrystallization from pyridine/water.

Quellen und Nachweise

ORD-Eintrag
ord-99b0e3e06ca044a98979c9cafc1f2c07
Quelldatensatz
uspto-grants-1985_12
Patentnummer
US04560692

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