Hydrazine hydrate (1:1) → 1-Amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one

HRID 63833Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 63833
Cl[CH2:2][CH2:3][N:4]([CH2:14][C:15]([F:18])([F:17])[F:16])[C:5](=O)[O:6]C1C=CC=CC=1.[NH2:19][NH2:20].O>C(O)C>[NH2:19][N:20]1[CH2:2][CH2:3][N:4]([CH2:14][C:15]([F:18])([F:17])[F:16])[C:5]1=[O:6]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 118047012Phenyl N-(2-chloroethyl)-N-(2,2,2-trifluoroethyl)carbamate

Produkt 1

HCID 867756191-Amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Into a 250-mL round-bottom flask, was placed a solution of phenyl N-(2-chloroethyl)-N-(2,2,2-trifluoroethyl)carbamate (5.6 g, 19.88 mmol, 1.00 equiv) in ethanol (100 mL), NH2NH2.H2O (10 mL, 80%). The resulting solution was heated to reflux overnight in an oil bath. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate (1:1). This resulted in 0.8 g (22%) of 1-amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one as colorless oil. (ES, m/z): 184 [M+H]+

Aufarbeitung

  1. customInto a 250-mL round-bottom flask, was placed
  2. temperatureThe resulting solution was heated
  3. temperatureto reflux overnight in an oil bath
  4. concentrationThe resulting mixture was concentrated under vacuum
  5. customThis resulted in 0.8 g (22%) of 1-amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one as colorless oil

Quellen und Nachweise

ORD-Eintrag
ord-bde14ba1044f4cf1886949c643ee5a50
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447084B2

Notizen zur Reaktion

Wird geladen…