6-(Hydroxymethyl)-7-methyl-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one → HCID 21873676, Verbindung

HRID 639028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639028
[OH:1][CH2:2][C:3]1[C:4]([CH3:14])=[CH:5][C:6]2[S:7][CH2:8][C:9](=[O:13])[NH:10][C:11]=2[N:12]=1>C(Cl)Cl.O=[Mn]=O>[CH3:14][C:4]1[C:3]([CH:2]=[O:1])=[N:12][C:11]2[NH:10][C:9](=[O:13])[CH2:8][S:7][C:6]=2[CH:5]=1

Komponenten

4

Edukt 1

HCID 218736326-(Hydroxymethyl)-7-methyl-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one

Produkt 1

HCID 21873676HCID 21873676, VerbindungAusbeute 61,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 6-(hydroxymethyl)-7-methyl-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one (290 mg, 1.38 mmol) in MeCl2 (20 mL) and was added MnO2 (1.2 g, 13.8 mmol). The reaction was vigorously stirred at RT for 12 h and then filtered and the solvent was removed at reduced pressure. Purification provided 176 mg of the desired aldehyde: MS (ES) m/z 209 (M+H)+.

Aufarbeitung

  1. filtrationfiltered
  2. customthe solvent was removed at reduced pressure
  3. customPurification

Quellen und Nachweise

ORD-Eintrag
ord-6e949c2e4991463a958432052640c520
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691850B2

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