Dimethylformamide → HCID 86607493, Verbindung

HRID 639283Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639283
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][CH2:7][C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[CH2:14][N:13]3[C:21]([C:24]([OH:26])=O)=[CH:22][CH:23]=[C:12]3[CH2:11]2)=[O:9])=[CH:4][CH:3]=1.CN(C)C=O.C(Cl)(=O)C([Cl:37])=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[CH2:14][N:13]3[C:21]([C:24]([Cl:37])=[O:26])=[CH:22][CH:23]=[C:12]3[CH2:11]2)=[O:9])=[CH:27][CH:28]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 68680492HCID 68680492, Verbindung

Produkt 1

HCID 86607493HCID 86607493, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 10-[(4-chlorophenoxy)acetyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid of step A (0.33 mmol) in dichloromethane (3 mL) was added a drop of N,N-dimethylformamide followed by oxalyl chloride (0.532 mmol). After stirring for 0.5 hour at room temperature, the solution was heated to reflux for three hours. The solvent and excess oxalyl chloride were evaporated to yield the crude product, which was used without further purification.

Aufarbeitung

  1. temperaturethe solution was heated
  2. temperatureto reflux for three hours
  3. customThe solvent and excess oxalyl chloride were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-6c9236f8eef84f0fafc30e4cf5797497
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691848B2

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