Bromine → methyl 5-bromo-6-oxo-1H-pyrazine-3-carboxylate

HRID 639313Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639313
[OH:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([O:10][CH3:11])=[O:9])=[N:6][CH:7]=1.[Br:12]Br>C(Cl)(Cl)Cl>[CH3:11][O:10][C:8]([C:5]1[CH:4]=[N:3][C:2]([OH:1])=[C:7]([Br:12])[N:6]=1)=[O:9]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 178498852HCID 178498852, Verbindung

Produkt 1

HCID 178498844methyl 5-bromo-6-oxo-1H-pyrazine-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A mixture of 2 g (13 mmol) methyl 5-hydroxypyrazine-2-carboxylate (commercially available), 0.192 g (0.65 mmol) FeBr3, 0.7 mL (14 mmol) Br2 in 20 mL CHCl3 was refluxed for 16 h. After evaporation of all volatiles the residue was used without further purification in the consecutive step.

Aufarbeitung

  1. temperaturewas refluxed for 16 h
  2. customAfter evaporation of all volatiles the residue
  3. customwas used without further purification in the consecutive step

Quellen und Nachweise

ORD-Eintrag
ord-d267403c5fb9427d90223a22bfd46cf5
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691863B2

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