Sulfuric Acid → 4-amino-1-benzyl-6-(trifluoromethyl)-3H-imidazo[4,5-c]pyridin-2-one

Temperatur

0 °C

1-Benzyl-4-benzylamino-6-trifluoromethyl-1,3-dihydro-imidazo[4,5-c]pyridine-2-one (2.63 g, 6.60 mmol) was dissolved in c.H2SO4 (50 ml) and the reaction mixture was stirred at room temperature for 30 minutes. The reaction mixture was cooled to 0° C. and ice was added. K2CO3 (150 g) was dissolved in water (700 ml) and the reaction mixture was added dropwise. The aqueous was extracted with EtOAc (6×500 ml). The combined organics were washed with brine (200 ml), dried over MgSO4 and concentrated in vacuo to give the title compound (1.20 g) as a white solid.

1. additionice was added
2. additionthe reaction mixture was added dropwise
3. extractionThe aqueous was extracted with EtOAc (6×500 ml)
4. washThe combined organics were washed with brine (200 ml)
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo

ORD-Eintrag

ord-7e8137780a6043e899162e1b3ded48ed

Quelldatensatz

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07691877B2