Hydrochloric Acid → HCID 68547925, Verbindung

HRID 639859Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639859
[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]23[CH2:15][C@@:14]2([CH2:16][O:17][CH3:18])[CH2:13][N:12]([CH3:19])[CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]23[CH2:15][C@@:14]2([CH2:16][O:17][CH3:18])[CH2:13][N:12]([CH3:19])[CH2:11][CH2:10]3)[CH:5]=[CH:6][C:7]=1[Cl:8]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 24802847HCID 24802847, Verbindung

Produkt 1

HCID 68547925HCID 68547925, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

(1S,6R)-6-(3,4-dichlorophenyl)-3-methyl-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane (E12, 16 mg) was treated with hydrochloric acid 1.0M in diethyl ether (0.064 mL). 0.5 mL of diethyl ether were added and a colourless solid formed. Organic phase was removed after decantation of the solid. Colourless solid obtained as a 5:1 mixture of isomers due protonation on the nitrogen atom (16 mg).

Aufarbeitung

  1. customa colourless solid formed
  2. customOrganic phase was removed after decantation of the solid
  3. customColourless solid obtained as a 5:1 mixture of isomers due protonation on the nitrogen atom (16 mg)

Quellen und Nachweise

ORD-Eintrag
ord-77dbcab9c8b4481aaacbf804ba142cb9
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691893B2

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