HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine → 1-[6-Methoxy-1-(methylsulfonyl)-4-phenylisoquinolin-3-yl]-n,n-dimethylmethanamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine | HCID 11738916 | — |
| Edukt | HCID 178504973 | HCID 178504973 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 1-[6-Methoxy-1-(methylsulfonyl)-4-phenylisoquinolin-3-yl]-n,n-dimethylmethanamine | HCID 11462849 | — |
Reaktionsschritte
A mixture of 1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine (75 mg), 1 mL DMF, and MeSO2Na (41 mg) was stirred at 80 C for 48 h, then at 100 C for 96 h. The solution was cooled and purified directly by reverse-phase HPLC to give the titled compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07691879B2 |
| Quelldatensatz | uspto-grants-2010_04 |
| ORD ID | ord-0a0a946d7c5749b1aebd3fceb7a49715 |
| Quellennotiz | uspto-grants-2010_04 |