Hydrochloric Acid → (E)-1-(Benzyloxy)-4-(2-nitrovinyl)benzene

HRID 640075

Reaktionsgleichung

Reaktionsgleichung von HRID 640075
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[Na+].[N+:20]([CH3:23])([O-:22])=[O:21].Cl>CO>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12](/[CH:13]=[CH:23]/[N+:20]([O-:22])=[O:21])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 6375NitromethaneHCID 78109Benzaldehyde, 4-(phenylmethoxy)-HCID 10942334Sodium Methoxide2×

Produkt 1

HCID 5702926(E)-1-(Benzyloxy)-4-(2-nitrovinyl)benzeneAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a mixture of 4-benzyloxybenzaldehyde (1.0 g, 4.7 mmol) and sodium methoxide (28% methanol solution, 150 μL, 0.74 mmol) and methanol (10 mL) were added nitromethane (330 μL, 6.1 mmol) and sodium methoxide (28% methanol solution, 1.0 mL, 4.9 mmol) at 0° C., which was stirred for 10 minutes at room temperature. The reaction mixture was cooled to 0° C., and 5 N aqueous hydrochloric acid solution (20 mL) was added thereto at the same temperature. The reaction mixture was then stirred for 15 minutes at room temperature. The precipitated solids were filtered to obtain the title compound (1.2 g, 100%).

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to 0° C.
  2. stirringThe reaction mixture was then stirred for 15 minutes at room temperature
  3. filtrationThe precipitated solids were filtered

Quellen und Nachweise

ORD-Eintrag
ord-3dedb112fb704cc2a400c83b2e7b1cce
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691882B2

Verknüpfte Notizen

Wird geladen…