HCID 86608383, Verbindung → HCID 68517032, Verbindung

HRID 641178Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 641178
[N:1]([C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[N:7]=[C:6]([O:16][CH2:17][C:18]([CH3:21])([OH:20])[CH3:19])[CH:5]=1)=[N+]=[N-]>O1CCCC1.CO.[Pd]>[NH2:1][C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[N:7]=[C:6]([O:16][CH2:17][C:18]([CH3:21])([OH:20])[CH3:19])[CH:5]=1

Komponenten

5

Edukt 1

HCID 86608383HCID 86608383, Verbindung

Produkt 1

HCID 68517032HCID 68517032, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1-(6-azido-2-morpholin-4-yl-pyrimidin-4-yloxy)-2-methyl-propan-2-ol was dissolved in a mixture of tetrahydrofuran (200 mL) and methanol (20 mL). To the solution was added 10% palladium on carbon (2 g) and the reaction was stirred under an atmosphere of hydrogen for 24 hours. The reaction was then filtered through celite and evaporated to give 1-(6-amino-2-morpholin-4-yl-pyrimidin-4-yloxy)-2-methyl-propan-2-ol (2.0 g).

Aufarbeitung

  1. filtrationThe reaction was then filtered through celite
  2. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-413f002dab504502a1f2dbff301a3987
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07696202B2

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