Chloroform → 2-Propyloxybenzamidine Hydrochloride

Temperatur

2.5 °C

21.41 g (400 mmol) of ammonium chloride are suspended in 400 ml of toluene and cooled to 0-5° C. 200 ml of a 2M solution of triethylaluminium in hexane are added dropwise, and the mixture is stirred at room temperature until the evolution of gas has ceased. After addition of 32.2 g (200 mmol) of 2-propoxybenzonitrile, the reaction mixture is stirred at 80° C. (bath) overnight. With ice-cooling, the cooled reaction mixture is added to a suspension of 300 g of silica gel and 2.85 l of ice-cooled chloroform, and the mixture is stirred for 30 minutes. The mixture is filtered off with suction and the filter residue is washed with the same amount of methanol. The solvent is distilled off under reduced pressure, the residue is stirred with 500 ml of a mixture of dichloromethane and methanol (9:1), the solid is filtered off and the mother liquor is concentrated. The residue is stirred with petroleum ether and filtered off with suction. This gives 22.3 g (52%) of product.

1. stirringthe reaction mixture is stirred at 80° C. (bath) overnight
2. temperatureWith ice-cooling
3. customthe cooled reaction mixture
4. stirringthe mixture is stirred for 30 minutes
5. filtrationThe mixture is filtered off with suction
6. washthe filter residue is washed with the same amount of methanol
7. distillationThe solvent is distilled off under reduced pressure
8. stirringthe residue is stirred with 500 ml of a mixture of dichloromethane and methanol (9:1)
9. filtrationthe solid is filtered off
10. concentrationthe mother liquor is concentrated
11. stirringThe residue is stirred with petroleum ether
12. filtrationfiltered off with suction

ORD-Eintrag

ord-4aee42dcce86416cb92b75b532475fb1

Quelldatensatz

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07696206B2