Sulfuric Acid → 4-(Pyrrolidin-1-YL)benzenesulfonic acid

HRID 641910

Reaktionsgleichung

[OH:1][S:2]([OH:5])(=O)=[O:3].[C:6]1([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(OCC)C>[N:12]1([C:6]2[CH:11]=[CH:10][C:9]([S:2]([OH:5])(=[O:3])=[O:1])=[CH:8][CH:7]=2)[CH2:16][CH2:15][CH2:14][CH2:13]1

Komponenten

Reaktionsbedingungen

Temperatur: 170 °C

Versuchsvorschrift

A solution of H2SO4 (6.8 g, 68.00 mmol) in diethylether (80 mL) was added to 1-phenylpyrrolidine (10 g, 68.03 mmol) in diethylether (20 mL) at 0° C. The diethylether was decanted, and the resulting solution was stirred for 3 hours at 170° C., then concentrated in vacuo to afford 7.3 g (43%) of 4-(pyrrolidin-1-yl)benzenesulfonic acid as a white solid.

Aufarbeitung

customThe diethylether was decanted
concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-fcdcf67793a74eb0b5e9c1631abd2ed2
Quelldatensatz: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07696229B2

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