Methyl Ethyl Ketone → 3-(4-(3,4-Dichlorophenyl)piperazine-1-yl)propan-1-ol

HRID 64218

Reaktionsgleichung

Reaktionsgleichung von HRID 64218
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].C(=O)([O-])[O-].[K+].[K+].C[C:22](=[O:25])[CH2:23][CH3:24]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:24][CH2:23][CH2:22][OH:25])[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Komponenten

4

Edukt 3

HCID 6569Methyl Ethyl KetoneHCID 11430Potassium CarbonateHCID 936011-(3,4-Dichlorophenyl)piperazine

Produkt 1

HCID 130979303-(4-(3,4-Dichlorophenyl)piperazine-1-yl)propan-1-ol

Versuchsvorschrift

Compound 5 (0.32 mL, 3.54 mmols) was mixed with 4-(3,4-dichlorophenyl)piperazine (0.58 g, 2.5 mmols) and potassium carbonate (0.78 g, 5.6 mmols) in 15 ml 2-butanone overnight at 85° C. as described in General Procedure B to yield compound 7p and was used as is for the next reaction. MS (LC/MS, ESI): 289 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-b2b44e96151540e98a8efe67154bbde0
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447122B2

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