Benzyl Bromide → Tri-O-benzyl-D-glucal

3,4,6-Tri-O-acetyl-D-glucal (5.0 g, 18.4 mmol) was dissolved in methanol (100 mL) and a solution of sodium methoxide in methanol (0.25 mL, 25% solution by weight, 1.1 mmol). The solution was stirred at room temperature for 3 hours. The solvent was removed and the resulting residue was co-evaporated with toluene (3×10 mL) before being taken up in a 4:1 solution of NMP:THF and cooled to 0° C. Solid NaH (3.3 g of 60% suspension, 82.5 mmol) was added and the mixture was stirred for 30 minutes before the addition of BnBr. The reaction mixture was stirred at room temperature overnight, quenched with methanol and the solvent removed. The residue was suspended in ethyl acetate, washed with 1 N HCl, brine, and saturated NaHCO3 (100 mL each). The ethyl acetate solution was dried over MgSO4, filtered and concentrated in vacuo. The crude material was purified on a silica gel column (80 g) using an ISCO automated chromatography system, eluting with a 0→50% gradient of ethyl acetate in heptane, to give 3,4,6-tri-O-benzyl-D-glucal (7.2 g, 94%).

1. customThe solvent was removed
2. temperatureTHF and cooled to 0° C
3. stirringThe reaction mixture was stirred at room temperature overnight
4. customquenched with methanol
5. customthe solvent removed
6. washwashed with 1 N HCl, brine, and saturated NaHCO3 (100 mL each)
7. dry with materialThe ethyl acetate solution was dried over MgSO4
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. customThe crude material was purified on a silica gel column (80 g)
11. washeluting with a 0→50% gradient of ethyl acetate in heptane

ORD-Eintrag

ord-a439f42121d748c296f33bb2770546ba

Quelldatensatz

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09447133B2