2,2,2,4'-Tetrafluoroacetophenone → 2,2,2-Trifluoro-1-(4-fluorophenyl)ethanol

Temperatur

25 °C

To a stirred solution of 2,2,2,4′-tetrafluoroacetophenone (10 g, 52.1 mmol) in methanol (50 mL) was added NaBH4 (0.98 g, 26.5 mmol) at 0° C. After stirring at 25° C. for 2 h, the reaction mixture was quenched by adding 1N HCl (100 mL) and then extracted with ethyl ether. The ether extract was washed with brine, dried with MgSO4, and concentrated to give 2,2,2-trifluoro-1-(4-fluorophenyl)ethanol (11.32 g) which was used in next step without further purification.

1. customthe reaction mixture was quenched
2. additionby adding 1N HCl (100 mL)
3. extractionextracted with ethyl ether
4. extractionThe ether extract
5. washwas washed with brine
6. dry with materialdried with MgSO4
7. concentrationconcentrated

ORD-Eintrag

ord-c19864ec4263411ab3e3e915a509ca58

Quelldatensatz

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07696250B2