Ammonia → 3,4-Dichloro-5-isothiazolecarboxylic acid amide

HRID 642919Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 642919
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([C:8](Cl)=[O:9])[S:4][N:3]=1.[NH3:11]>O>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([C:8]([NH2:11])=[O:9])[S:4][N:3]=1

Komponenten

4

Edukt 2

HCID 222Ammonia2×HCID 109768863,4-Dichloro-5-isothiazolecarbonyl chloride

Produkt 1

HCID 113330673,4-Dichloro-5-isothiazolecarboxylic acid amideAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

At 0 to 10° C., 50.1 g (0.2 mol) of 3,4-dichloro-isothiazole-5-carbonyl chloride are added dropwise with stirring over a period of 30 minutes to 82 g (1.2 mol) of concentrated ammonia. After the addition, another 41 g (0.6 mol) of concentrated ammonia are added and the mixture is diluted with 70 ml of water. The mixture is allowed to warm to room temperature and stirred at this temperature for 45 minutes. The resulting precipitate is filtered off with suction, washed successive with water and petroleum ether and dried. In this manner, 32.3 g (81.8% of theory) of 3,4-dichloro-isothiazole-5-carboxamide are obtained in the form of a solid of melting point 156 to 158° C.

Aufarbeitung

  1. additionAfter the addition
  2. filtrationThe resulting precipitate is filtered off with suction
  3. washwashed successive with water and petroleum ether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0d80440c6e0145608b994dc1833c5b36
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07696355B2

Notizen zur Reaktion

Wird geladen…