HCID 136928067, Verbindung → HCID 136928110, Verbindung

HRID 64308Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 64308
C([N:8]1[CH2:13][CH2:12][C:11]2([N:17]3[N:18]=[C:19]([C:24]4[CH:29]=[CH:28][C:27]([O:30][C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:26][CH:25]=4)[C:20]([C:21]([NH2:23])=[O:22])=[C:16]3[NH:15][CH2:14]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.CC(O)=O.[OH-].[OH-].[Pd+2]>[O:30]([C:27]1[CH:26]=[CH:25][C:24]([C:19]2[C:20]([C:21]([NH2:23])=[O:22])=[C:16]3[NH:15][CH2:14][C:11]4([CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[N:17]3[N:18]=2)=[CH:29][CH:28]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Komponenten

5

Edukt 1

HCID 136928067HCID 136928067, Verbindung

Produkt 1

HCID 136928110HCID 136928110, VerbindungAusbeute 51,4 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidKatalysatorHCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 1′-benzyl-6-(4-phenoxyphenyl)-1,2-dihydrospiro[imidazo[1,2-b]pyrazole-3,4′-piperidine]-7-carboxamide (50 mg, 0.10 mmol), 10% w/w Pd(OH)2/C (5 mg) in MeOH (10 mL) and HOAc (1 drop) was stirred for 16 hr under H2. The mixture was filtrated and the filtrate was concentrated to give the crude product (20 mg 51.4%) as a yellow solid. MS (ESI, m/e) [M+1]+ 390.0.

Aufarbeitung

  1. filtrationThe mixture was filtrated
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-2eeb7802e5a74bebb486d86771d06c3a
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447106B2

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